Victor Boniface rattled the post with a powerful shot eight minutes after the restart as Leverkusen picked up where they had left off.
Bayer Leverkusen won their first trophy in 31 years with five matches left in the season, snapping Bayern Munich's 11-year stranglehold on the Bundesliga.
Bayer Leverkusen are the first team in the history of the Bundesliga to complete a full season without a loss.
Atalanta beat Bayer Leverkusen 3-0 in the Europa League final
Barcelona striker Robert Lewandowski scored twice to set his side on course for a 5-0 Champions League thrashing of Swiss side Young Boys on Tuesday as the Catalan giants bounced back from a 2-1 loss at AS Monaco in their opener.
Barcelona captain Raphinha scored twice as they returned to winning ways in LaLiga for the first time in a month with a 5-1 victory at Mallorca on Tuesday.
Barcelona's Robert Lewandowski scored a quick-fire second-half double to set the leaders on course for a thrashing of Real Madrid.
Robert Lewandowski's brace earned depleted Barcelona a 2-1 comeback win at Valencia
A round-up of Wednesday's UEFA Champions League last-16 first leg matches.
Real Madrid have avoided defeat in their last 41 LaLiga games, the second best streak by a team in the competition's history.
Bayer Leverkusen crushed hosts VfL Bochum 5-0 to stretch their remarkable unbeaten run across all competitions this season to 50 consecutive matches.
Paris St Germain closed out the year on a high as they maintained their five-point advantage at the top of the table.
Leverkusen's Schick scores hat-trick in comeback win over Heidenheim.
Barcelona made a disappointing start to their Champions League campaign by losing 2-1 to AS Monaco on Thursday.
IMAGES from the UEFA Champions League matches played on Wednesday.
Images from football matches held across Europe on Saturday
IMAGES from the football matches played across Europe on Sunday.
